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They used a hydroquinone-induced vitiligo mouse model and human epidermal melanocyte cell lines (PIG1 and PIG3V)

The researchers utilized the Achilles functional index (AFI), myeloperoxidase activity, histological inflammatory cell influx, and vascular index as potential markers

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-defensins (HD-5 and HD-6), expressed mainly by Paneth cells in the small intestine, and -defensins (hBD1 to hBD-4), expressed by epithelial cells throughout the intestine, possess antimicrobial activity against a wide range of variety of bacteria, fungi, and some viruses and are constitutively expressed to prevent pathogens from reaching the epithelium